The OPP reopened the westbound lanes of Highway 401 just after 9:30 a.m. at Kent Bridge Road, as cleanup efforts are finishing up after a tractor-trailer spilled its load.
Police say shortly before 2 a.m., a big-rig carrying 32 tonnes of auto parts drove into the median and then back onto the road before rolling over into the passing lane.
The driver was taken to hospital with minor injuries.
Police believe fatigue was a factor.
Charges are pending.